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	LIPID Metabolites And Pathways Strategy

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Data

Lipid Classification Scheme

The LIPID MAPS Lipid Classification Scheme
is comprised of eight categories containing distinct classes and subclasses of molecules, chemically based and driven by the distinct hydrophobic and hydrophilic elements that compose the lipid.

You can view the complete list of LIPID MAPS lipids, organized by category, class, and subclass, with links to corresponding Wikipedia pages (where available). You can also drill down from lipid category to the LMSD record for an individual lipid, where you will find annotations, crosslinks to external databases, and a structure image, with links to structure viewing tools.

Component ("Parts List") Databases

• Structure Database (LMSD)
  The LIPID MAPS Structure Database (LMSD) is comprised of structures and annotations of biologically relevant lipids, and includes representative examples from each category of the LIPID MAPS Lipid Classification scheme.
• Proteome Database (LMPD)
  Lipid-associated protein sequences with annotations from UniProt, EntrezGene, ENZYME, GO, KEGG and other public resources. Browse or search by species, lipid class association, and/or keywords.

Standards

• Lipid Standards
  These analytical standards include
  • MS/MS value (nominal mass of precursor ion in negative-ion mode), with links to fragmentation spectrum, including structures of principal product ions.
  • Links to Cayman catalog product descriptions for Eicosanoids
  • Literature reference(s) pertaining to identification of fragment structures.

Experimental Results

Lipidomics Studies on Macrophages

• RAW 264.7 cells
  • Kdo2-lipid A Timecourse Experiments
  • Compactin/Kdo2-lipid A Timecourse Experiments

• Primary Macrophages
  • Thioglycolate-elicited peritoneal Macrophages
    • Foam cell study with wild-type and LDLR(-/-) mice
    • Thioglycolate-elicited Macrophage Timecourse Experiments
    • Compare TGEM and BMDM cell Timecourse Experiments (0,6,24 hrs)
    • Compare TGEM, BMDM and RAW cell Timecourse Experiments for sterols(full timecourse)
  • Bone marrow-derived Macrophages
    • Bone marrow-derived Macrophage Timecourse Experiments

Gene array data on Macrophages

• RAW 264.7 cells
  • Kdo2-lipid A Timecourse Experiments
  • Compactin/Kdo2-lipid A Timecourse Experiments

• Primary Macrophages
  • Thioglycolate-elicited Macrophages
    • Foam cell study with LDLR(-/-) and wild-type mice
    • Thioglycolate-elicited Macrophage Timecourse Experiments
  • Bone marrow-derived Macrophages
    • Bone marrow-derived Macrophage Timecourse Experiments