July, 2014 update

    • LIPID MAPS Highlights

      more highlights

    • Lipid of the month


      Spisulosine
      Spisulosine (1-deoxy-sphinganine) is a sphingoid base analog of sphinganine where the C1-hydroxyl group is absent and therefore cannot be metabolized to complex sphingolipids nor degraded by the regular sphingolipid catabolism pathway. It is biosynthesized by Serine Palmitoyltransferase (SPT) from palmitoyl-CoA and alanine, where alanine replaces serine as the amino-acid substrate. Inhibition of ceramide synthases by the mycotoxin Fumonisin B causes accumulation of 1-deoxysphinganine, leading to kidney and liver toxicity and other diseases.

Key LIPID MAPS Resources
Publications
- publications related to projects funded through the LIPID MAPS consortium
Lipid Classification System
- the first internationally accepted lipid classification system
Lipid Standards
- MS/MS spectra, annotations for principal product ions, and acquisition parameters
Experimental Data
- centralized studies on macrophages, lipidomics data on human plasma, and more
Structure Database (LMSD)
- over 37,000 unique structures of biologically relevant lipids
Proteome Database (LMPD)
- over 2,400 lipid-associated proteins from human and mouse
Pathways
- manually curated lipid metabolism and signaling pathways
MS analysis tools
- tools for searching various lipid classes by precursor or product ion
Structure Drawing Tools
- draw and save lipid structures using online menus
Protocols
- LIPID MAPS techniques for lipidomics and macrophage cell culture


LIPID MAPS is funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health.

logo LIPID MAPS is funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health.