LMPD Database

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LMP002476

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor
Protein EntryLDLR_MOUSE
UniProt IDP35951
SpeciesMouse
Comments
Comment typeDescription
DomainThe NPXY motif mediates the interaction with the clathrin adaptor DAB2 involved in receptor internalization. {ECO:0000269|PubMed:11247302}.
FunctionBinds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
PtmUbiquitinated by MYLIP leading to degradation. {ECO:0000250}.
SimilarityBelongs to the LDLR family. {ECO:0000305}.
SimilarityContains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 6 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
SimilarityContains 7 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}.
Subcellular LocationCell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus {ECO:0000250}. Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Cell surface {ECO:0000250}. Lysosome {ECO:0000250}. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 (By similarity). {ECO:0000250}.
SubunitInteracts with LDLRAP1, ARRB1, SNX17. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts with the full length immature form of PCSK9 (via C-terminus). {ECO:0000269|PubMed:11247302, ECO:0000269|PubMed:12169628}.