LMPD Database

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LMP012343

UniProt Annotations

Entry Information
Gene Nameleptin
Protein Entry
UniProt IDP41159
SpeciesHuman
Comments
Comment typeDescription
DiseaseLeptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionMay function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
SimilarityBelongs to the leptin family
Subcellular LocationSecreted.
SubunitInteracts with SIGLEC6
Web ResourceName=R&D Systems' cytokine mini-reviews: Leptin; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1773";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/lep/";
Web ResourceName=Wikipedia; Note=Leptin entry; URL="http://en.wikipedia.org/wiki/Leptin";