LMPD Database

LMP012343

Gene Information

Entrez Gene ID	3952
Gene Name	leptin
Gene Symbol	LEP
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:Ensembl	C	cytoplasm
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	ISS:HGNC	C	extracellular space
GO:0060612	IEA:Ensembl	P	adipose tissue development
GO:0008343	ISS:HGNC	P	adult feeding behavior
GO:0008206	IEA:Ensembl	P	bile acid metabolic process
GO:0035630	IEA:Ensembl	P	bone mineralization involved in bone maturation
GO:0071298	IEA:Ensembl	P	cellular response to L-ascorbic acid
GO:0071300	IEA:Ensembl	P	cellular response to retinoic acid
GO:0021954	IEA:Ensembl	P	central nervous system neuron development
GO:0008203	IEA:Ensembl	P	cholesterol metabolic process
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0042755	IEA:Ensembl	P	eating behavior
GO:0006112	TAS:ProtInc	P	energy reserve metabolic process
GO:0006635	IEA:Ensembl	P	fatty acid beta-oxidation
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0042593	IEA:Ensembl	P	glucose homeostasis
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0006114	IEA:Ensembl	P	glycerol biosynthetic process
GO:0042445	IEA:Ensembl	P	hormone metabolic process
GO:0030073	IEA:Ensembl	P	insulin secretion
GO:0033210	IEA:Ensembl	P	leptin-mediated signaling pathway
GO:0050901	IEA:Ensembl	P	leukocyte tethering or rolling
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0032099	ISS:HGNC	P	negative regulation of appetite
GO:0061037	IEA:Ensembl	P	negative regulation of cartilage development
GO:0070093	IEA:Ensembl	P	negative regulation of glucagon secretion
GO:2000486	IEA:Ensembl	P	negative regulation of glutamine transport
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0045906	IEA:Ensembl	P	negative regulation of vasoconstriction
GO:0001542	IEA:Ensembl	P	ovulation from ovarian follicle
GO:0001890	IDA:DFLAT	P	placenta development
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0001819	IEA:Ensembl	P	positive regulation of cytokine production
GO:0048639	IDA:DFLAT	P	positive regulation of developmental growth
GO:0046881	IEA:Ensembl	P	positive regulation of follicle-stimulating hormone secretion
GO:2000491	IEA:Ensembl	P	positive regulation of hepatic stellate cell activation
GO:0046628	IEA:Ensembl	P	positive regulation of insulin receptor signaling pathway
GO:0043270	IEA:Ensembl	P	positive regulation of ion transport
GO:0033686	IEA:Ensembl	P	positive regulation of luteinizing hormone secretion
GO:0043410	IEA:Ensembl	P	positive regulation of MAPK cascade
GO:0045639	IEA:Ensembl	P	positive regulation of myeloid cell differentiation
GO:2000366	IEA:Ensembl	P	positive regulation of STAT protein import into nucleus
GO:0042517	IEA:Ensembl	P	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0008217	IEA:Ensembl	P	regulation of blood pressure
GO:0045598	IEA:Ensembl	P	regulation of fat cell differentiation
GO:0006111	IEA:Ensembl	P	regulation of gluconeogenesis
GO:0050796	IEA:Ensembl	P	regulation of insulin secretion
GO:0030300	IEA:Ensembl	P	regulation of intestinal cholesterol absorption
GO:0060587	IEA:Ensembl	P	regulation of lipoprotein lipid oxidation
GO:0050810	IEA:Ensembl	P	regulation of steroid biosynthetic process
GO:0002021	IEA:Ensembl	P	response to dietary excess
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0007260	IEA:Ensembl	P	tyrosine phosphorylation of STAT protein

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04920	Adipocytokine signaling pathway
ko04920	Adipocytokine signaling pathway
hsa04152	AMPK signaling pathway
ko04152	AMPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
ko04060	Cytokine-cytokine receptor interaction
hsa04630	Jak-STAT signaling pathway
ko04630	Jak-STAT signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
ko04080	Neuroactive ligand-receptor interaction
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
ko04932	Non-alcoholic fatty liver disease (NAFLD)

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111045	Developmental Biology
REACT_23974	Incretin synthesis, secretion, and inactivation
REACT_17015	Metabolism of proteins
REACT_160078	Peptide hormone metabolism
REACT_169118	Signaling by Leptin
REACT_111102	Signal Transduction
REACT_19189	Synthesis, secretion, and deacylation of Ghrelin
REACT_24019	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_27161	Transcriptional regulation of white adipocyte differentiation