LMPD Database

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LMP012629

UniProt Annotations

Entry Information
Gene Namesolute carrier family 22 (organic cation/carnitine transporter), member 5
Protein EntryS22A5_RAT
UniProt IDO70594
SpeciesRat
Comments
Comment typeDescription
FunctionSodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
SimilarityBelongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family
Subcellular LocationMembrane; Multi-pass membrane protein.
SubunitInteracts with PDZK1
Tissue SpecificityExpressed in the proximal and distal tubules and in the glomeruli in the kidney, in the myocardium, valves, and arterioles in the heart, in the labyrinthine layer of the placenta, and in the cortex, hippocampus, and cerebellum in the brain.