LMPD Database

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LMP012461

UniProt Annotations

Entry Information

Gene Name	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Protein Entry	FCERA_RAT
UniProt ID	P12371
Species	Rat

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P12371-1; Sequence=Displayed; Name=2; IsoId=P12371-2; Sequence=VSP_012760, VSP_012761;
Function	Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Induction	Exhibits night/day variations with a 15-fold increased expression at night in the pineal gland. Up-regulation is due to a large degree to the release of norepinephrine from nerve terminals in the pineal gland and cAMP signaling pathway (at protein level)
Similarity	Contains 2 Ig-like (immunoglobulin-like) domains
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location	Isoform 2: Secreted.
Subunit	Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
Tissue Specificity	Expressed in leukocytes and pinealocytes at night (at protein level). {ECO:0000269\|PubMed:17728245, ECO:0000269\|PubMed:19103603}.