LMPD Database

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LMP012123

UniProt Annotations

Entry Information
Gene Nameclavesin 2
Protein EntryCLVS2_DANRE
UniProt IDQ5SPP0
SpeciesZebrafish
Comments
Comment typeDescription
DomainThe CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2. {ECO:0000250}.
FunctionRequired for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). {ECO:0000250}.
MiscellaneousBinding to PtdIns(3,5)P2 is not required for localization. {ECO:0000250}.
SimilarityContains 1 CRAL-TRIO domain. {ECO:0000255|PROSITE- ProRule:PRU00056}.
Subcellular LocationGolgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}.