LMPD Database

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LMP012116

UniProt Annotations

Entry Information
Gene Namelysyl oxidase-like 2a
Protein EntryLOL2A_DANRE
UniProt IDF1QQC3
SpeciesZebrafish
Comments
Comment typeDescription
Catalytic ActivityPeptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2).
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250};
CofactorName=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Evidence={ECO:0000250}; Note=Contains 1 lysine tyrosylquinone. {ECO:0000250};
Developmental StageExpression increases between 20 and 48 hours after fertilization and is detected in sprouting intersegmental vessels. {ECO:0000269|PubMed:21835952}.
FunctionMediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When nuclear, acts as a transcription corepressor and probably specifically mediates deamination of histone H3. Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. {ECO:0000250, ECO:0000269|PubMed:21835952}.
PtmThe lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250}.
SimilarityBelongs to the lysyl oxidase family. {ECO:0000305}.
SimilarityContains 4 SRCR domains. {ECO:0000255|PROSITE- ProRule:PRU00196}.
Subcellular LocationSecreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromatin (By similarity). It is unclear how loxl2a is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. {ECO:0000250}.