LMPD Database

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LMP011130

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 2C 3
Protein EntryP2C03_ARATH
UniProt IDQ9LNW3
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO:0000250};
FunctionInvolved in the negative regulation of the K(+) potassium channel AKT1 by its dephosphorylation, antagonistically to CIPK proteins (e.g. CIPK23). {ECO:0000269|PubMed:17898163}.
SimilarityBelongs to the PP2C family. {ECO:0000305}.
SimilarityContains 1 PP2C-like domain. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}. Note=Probably associated to the plasma membrane when interacting with AKT1 and CIPK23.
SubunitPart of a K(+)-channel calcium-sensing kinase/phosphatase complex composed by a calcium sensor CBL (CBL1, CBL2, CBL3 or CBL9), a kinase CIPK (CIPK6, CIPK16 or CIPK23), a phosphatase PP2C (AIP1) and a K(+)-channel (AKT1). Interacts with AKT1 and CIPK23. {ECO:0000269|PubMed:17898163}.