LMPD Database

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LMP010765

UniProt Annotations

Entry Information
Gene Nameperoxin 19-2
Protein EntryPE192_ARATH
UniProt IDQ94EI3
SpeciesArabidopsis
Comments
Comment typeDescription
CautionLike its mammalian and yeast counterparts, PEX19-2 might be farnesylated and interacting transiently with the peroxisome membrane. However, this post-translational modification has not been demonstrated and only a trace of PEX19 was found associated with the peroxisome (PubMed:16923726). {ECO:0000305|PubMed:16923726}.
FunctionContributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer. {ECO:0000269|PubMed:16923726, ECO:0000269|PubMed:17478547}.
InteractionQ94FB9:ABCC1; NbExp=2; IntAct=EBI-7933092, EBI-7933055;
PtmMay be farnesylated. {ECO:0000250}.
Sequence CautionSequence=CAC01899.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the peroxin-19 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16923726}. Peroxisome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Predominantly cytoplasmic.
SubunitDimer. Interacts with PEX10 (via C-terminus) (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in roots, leaves, flowers, siliques and stems. Highest expression in roots and leaves. {ECO:0000269|PubMed:16923726}.