LMPD Database

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LMP010363

UniProt Annotations

Entry Information
Gene Namegibberellin 20 oxidase 2
Protein EntryGAOX2_ARATH
UniProt IDQ39111
SpeciesArabidopsis
Comments
Comment typeDescription
CofactorName=2-oxoglutarate; Xref=ChEBI:CHEBI:16810;
CofactorName=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
CofactorName=L-ascorbate; Xref=ChEBI:CHEBI:38290;
Developmental StageExpressed in developing siliques 3-13 days after pollination. {ECO:0000269|PubMed:15927942}.
Disruption PhenotypeSlightly smaller than the wild type. {ECO:0000269|PubMed:18069939}.
FunctionKey oxidase enzyme in the biosynthesis of gibberellin that catalyzes the conversion of GA12 and GA53 to GA9 and GA20 respectively, via a three-step oxidation at C-20 of the GA skeleton. GA53 is less effectively oxidized than GA12, and GA25 is also formed as a minor product. Involved in the promotion of the floral transition, fertiliy and silique elongation, but plays only a minor role in elongation of seedling organs. Acts redundantly with GA20OX1. {ECO:0000269|PubMed:18069939}.
InductionNegatively controlled by the level of physiologically active gibberellin. Up-regulated by auxin, paclobutrazol, long day exposure and cold treatment. {ECO:0000269|PubMed:14729916, ECO:0000269|PubMed:15923331, ECO:0000269|PubMed:16905669, ECO:0000269|PubMed:18069939}.
PathwayPlant hormone biosynthesis; gibberellin biosynthesis.
SimilarityBelongs to the iron/ascorbate-dependent oxidoreductase family. GA20OX subfamily. {ECO:0000305}.
SimilarityContains 1 Fe2OG dioxygenase domain. {ECO:0000255|PROSITE-ProRule:PRU00805}.
Tissue SpecificityExpressed in inflorescence and developing siliques. Detected in seeds, roots, cotyledons and leaves. In seeds, specifically detected at the rim of the embryo and the outer integument. {ECO:0000269|PubMed:15927942, ECO:0000269|PubMed:16905669, ECO:0000269|PubMed:18069939, ECO:0000269|PubMed:7630935}.