LMPD Database

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LMP010150

UniProt Annotations

Entry Information
Gene NameDNA topoisomerase 6 subunit B
Protein EntryTOP6B_ARATH
UniProt IDQ9C5V6
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO:0000255|HAMAP-Rule:MF_03165}.
Disruption PhenotypePlants are defective in cell elongation and show a severe dwarf phenotype. {ECO:0000269|PubMed:12119417}.
FunctionComponent of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP. Involved in cell-elongation processes. {ECO:0000255|HAMAP-Rule:MF_03165, ECO:0000269|PubMed:12119417, ECO:0000269|PubMed:12401175}.
InteractionQ9LZ03:TOP6A; NbExp=3; IntAct=EBI-1772132, EBI-1772104;
Sequence CautionSequence=BAB02486.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the TOP6B family. {ECO:0000255|HAMAP- Rule:MF_03165}.
Subcellular LocationNucleus {ECO:0000255|HAMAP-Rule:MF_03165}.
SubunitHomodimer. Heterotetramer of two TOP6A and two TOP6B subunits. Interacts with SPO11-2, but not with SPO11-1, RHL1 or BIN4. {ECO:0000255|HAMAP-Rule:MF_03165, ECO:0000269|PubMed:11410368, ECO:0000269|PubMed:16339310, ECO:0000269|PubMed:18055605}.
Tissue SpecificityHighly expressed in leaves, stems, flowers and seedlings. {ECO:0000269|PubMed:11410368}.