LMPD Database

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LMP008133

UniProt Annotations

Entry Information
Gene NameProtein LIN-23
Protein EntryLIN23_CAEEL
UniProt IDQ09990
SpeciesC. elegans
Comments
Comment typeDescription
Developmental StageHighest levels in embryos and adults, lowest levels in larvae. Maternal expression results in high zygotic levels. {ECO:0000269|PubMed:11060233}.
FunctionFunctions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). {ECO:0000250}.
SimilarityContains 1 F-box domain. {ECO:0000255|PROSITE- ProRule:PRU00080}.
SimilarityContains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationCytoplasm {ECO:0000305}.
SubunitPart of a SCF (SKP1-cullin-F-box) protein ligase complex. {ECO:0000250}.