LMPD Database

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LMP006077

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase 1
Protein EntryGDE1_MOUSE
UniProt IDQ9JL56
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionHas glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity). {ECO:0000250}.
PtmN-glycosylated. {ECO:0000250}.
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family. {ECO:0000305}.
SimilarityContains 1 GP-PDE domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Perinuclear vesicles and cell membrane. {ECO:0000250}.
SubunitInteracts with PRAF2 and RGS16. {ECO:0000250}.
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10760272}.