LMPD Database

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LMP002888

Record overview

LMPD IDLMP002888
Gene ID11409
SpeciesMus musculus(Mouse)
Gene Nameacyl-Coenzyme A dehydrogenase, short chain
Gene SymbolAcads
SynonymsAI196007; Bcd-1; Bcd1; Hdlq8; SCAD
Alternate namesshort-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase
Chromosome5
Map Location5 F|5 55.99 cM
EC Number1.3.8.1
SummaryThis gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for Acads

Proteins

short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID:NP_031409
Protein GI:31982522
UniProt ID:Q07417
mRNA ID:NM_007383
Length:412
RefSeq Status:REVIEWED
MAAALLARARGPLRRALGVRDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSI
ALEEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAS
TDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAF
GAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRL
VIAGHLLRSYRS
 
transit_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q07417.2)
calculated_mol_wt: 2733
peptide sequence: 
MAAALLARARGPLRRALGVRDWRR

mat_peptide: 25..412
product: Short-chain specific acyl-CoA dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q07417.2)
calculated_mol_wt: 42175
peptide sequence: 
LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRACASTGVIMSVNNSLYL
GPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTL
GKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESA
RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS