LMPD Database

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LMP002477

UniProt Annotations

Entry Information
Gene Namephosphatidylethanolamine N-methyltransferase
Protein EntryPEMT_MOUSE
UniProt IDQ61907
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q61907-1; Sequence=Displayed; Name=2; IsoId=Q61907-2; Sequence=VSP_053224;
Catalytic ActivityS-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. {ECO:0000255|PROSITE- ProRule:PRU00931}.
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Catalytic ActivityS-adenosyl-L-methionine + phosphatidyl-N- methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N- dimethylethanolamine. {ECO:0000255|PROSITE-ProRule:PRU00931}.
FunctionCatalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Sequence CautionSequence=AAQ01190.1; Type=Frameshift; Positions=195; Evidence={ECO:0000305};
SimilarityBelongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU00931}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityLiver.