LMPD Database

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LMP002473

UniProt Annotations

Entry Information
Gene Nameprostaglandin E synthase 3 (cytosolic)
Protein EntryTEBP_MOUSE
UniProt IDQ9R0Q7
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15- dihydroxy-9-oxoprosta-5,13-dienoate. {ECO:0000250|UniProtKB:Q15185}.
FunctionCytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. {ECO:0000250|UniProtKB:Q15185}.
PathwayLipid metabolism; prostaglandin biosynthesis. {ECO:0000250|UniProtKB:Q15185}.
SimilarityBelongs to the p23/wos2 family. {ECO:0000305}.
SimilarityContains 1 CS domain. {ECO:0000255|PROSITE- ProRule:PRU00547}.
Subcellular LocationCytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
SubunitBinds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. {ECO:0000250|UniProtKB:Q15185}.
Tissue SpecificityExpressed in testis, kidney, bladder and ovary. {ECO:0000269|PubMed:14563409}.