LMPD Database

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LMP002386

UniProt Annotations

Entry Information
Gene Nameprostate transmembrane protein, androgen induced 1
Protein EntryPMEPA_HUMAN
UniProt IDQ969W9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=a; IsoId=Q969W9-1; Sequence=Displayed; Name=2; Synonyms=b; IsoId=Q969W9-2; Sequence=VSP_006438; Name=3; Synonyms=c; IsoId=Q969W9-3; Sequence=VSP_044588;
DomainThe SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling. {ECO:0000269|PubMed:20129061}.
DomainThe WW-binding motifs mediate interaction with NEDD4. {ECO:0000269|PubMed:18703514}.
FunctionFunctions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
InductionUp-regulated by androgen and TGF-beta (at protein level). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061}.
SimilarityBelongs to the PMEPA1 family. {ECO:0000305}.
Subcellular LocationEarly endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
SubunitInteracts with NEDD4 (WW-binding motifs). Interacts with AR. Interacts with LDLRAD4. Interacts (via the SMAD interaction motif) with SMAD2 and SMAD3. {ECO:0000269|PubMed:12907594, ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
Tissue SpecificityHighest expression in prostate. Also expressed in ovary.