LMPD Database

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LMP002386

Record overview

LMPD IDLMP002386
Gene ID56937
SpeciesHomo sapiens (Human)
Gene Nameprostate transmembrane protein, androgen induced 1
Gene SymbolPMEPA1
SynonymsSTAG1; TMEPAI
Chromosome20
Map Location20q13.31-q13.33
SummaryThis gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for PMEPA1

Proteins

protein TMEPAI isoform a
Refseq ID:NP_064567
Protein GI:21361841
UniProt ID:Q969W9
mRNA ID:NM_020182
Length:287
RefSeq Status:REVIEWED
MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVS
GNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSA
RLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
 
protein TMEPAI isoform b
Refseq ID:NP_954638
Protein GI:40317616
UniProt ID:Q5JY37
mRNA ID:NM_199169
Length:252
RefSeq Status:REVIEWED
MAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQP
TYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEV
IGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
 
protein TMEPAI isoform c precursor
Refseq ID:NP_954639
Protein GI:40317618
UniProt ID:Q5JY37
mRNA ID:NM_199170
Length:237
RefSeq Status:REVIEWED
MMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTI
SLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSS
GPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
 
protein TMEPAI isoform c precursor
Refseq ID:NP_954640
Protein GI:40317620
UniProt ID:Q969W9
mRNA ID:NM_199171
Length:237
RefSeq Status:REVIEWED
Protein sequence is identical to GI:40317618 (mRNA isoform)
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2139
peptide sequence: 
MMVMVVVITCLLSHYKLSA
 
protein TMEPAI isoform d
Refseq ID:NP_001242905
Protein GI:364023812
UniProt ID:Q969W9
mRNA ID:NM_001255976
Length:259
RefSeq Status:REVIEWED
MPAIPAHGAELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRE
RFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGP
PPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL