LMPD Database

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LMP002386

Gene Information

Entrez Gene ID56937
Gene Nameprostate transmembrane protein, androgen induced 1
Gene SymbolPMEPA1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031901 IDA:UniProtKBCearly endosome membrane
GO:0010008 IDA:UniProtKBCendosome membrane
GO:0000139 IDA:UniProtKBCGolgi membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0016021 NAS:UniProtKBCintegral component of membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0070412 IPI:UniProtKBFR-SMAD binding
GO:0050699 IPI:UniProtKBFWW domain binding
GO:0030521 NAS:UniProtKBPandrogen receptor signaling pathway
GO:0060394 IDA:UniProtKBPnegative regulation of pathway-restricted SMAD protein phosphorylation
GO:0010991 IDA:UniProtKBPnegative regulation of SMAD protein complex assembly
GO:0030512 IDA:UniProtKBPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer