LMPD Database

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LMP002287

UniProt Annotations

Entry Information
Gene Nameapolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Protein EntryABEC1_MOUSE
UniProt IDP51908
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
FunctionCatalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:21496894}.
SimilarityBelongs to the cytidine and deoxycytidylate deaminase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. Part of the apolipoprotein B mRNA editing complex with APC. Interacts with HNRPAB and SYNCRIP (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in the spleen. Expressed at lower level in the kidney, testis, lung, brain and liver. {ECO:0000269|PubMed:12859895}.