LMPD Database

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LMP002171

UniProt Annotations

Entry Information
Gene Nameserine palmitoyltransferase, long chain base subunit 1
Protein EntrySPTC1_MOUSE
UniProt IDO35704
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
FunctionSerine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By similarity). {ECO:0000250}.
PathwayLipid metabolism; sphingolipid metabolism.
PtmPhosphorylation at Tyr-164 inhibits activity and promotes cell survival. {ECO:0000250}.
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:1317856}; Single-pass membrane protein {ECO:0000269|PubMed:1317856}.
SubunitHeterodimer with SPTLC2 or SPTLC3. Component of the serine palmitoyltransferase (SPT) complex, composed of SPTLC1, either SPTLC2 or SPTLC3, and either SPTSSA or SPTSSB. Interacts with SPTSSA and SPTSSB; the interaction is direct. Interacts with ORMDL3 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in a variety of tissues. Highest expression in brain, kidney and liver.