LMPD Database

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LMP001473

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group VI (cytosolic, calcium-independent)
Protein EntryPLPL9_HUMAN
UniProt IDO60733
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=LH-iPLA2; IsoId=O60733-1; Sequence=Displayed; Name=SH-iPLA2; IsoId=O60733-2; Sequence=VSP_000278; Name=Ankyrin-iPLA2-1; IsoId=O60733-3; Sequence=VSP_000281, VSP_000282; Name=Ankyrin-iPLA2-2; IsoId=O60733-4; Sequence=VSP_000277, VSP_000279, VSP_000280;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DiseaseNeurodegeneration with brain iron accumulation 2A (NBIA2A) [MIM
DiseaseNeurodegeneration with brain iron accumulation 2B (NBIA2B) [MIM
DiseaseParkinson disease 14 (PARK14) [MIM
Enzyme RegulationInhibited by calcium-activated calmodulin.
FunctionCatalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.
FunctionIsoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
PharmaceuticalPotential target for therapeutic intervention of Barth syndrome.
SimilarityContains 1 patatin domain.
SimilarityContains 7 ANK repeats. {ECO
Subcellular LocationIsoform LH-iPLA2: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.
Subcellular LocationIsoform SH-iPLA2: Cytoplasm.
SubunitForms large oligomeric 270-350 kDa structures.
Tissue SpecificityFour different transcripts were found to be expressed in a distinct tissue distribution.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g6/";