LMPD Database

LMP001325

Gene Information

Entrez Gene ID	5290
Gene Name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Symbol	PIK3CA
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0030027	IEA:Ensembl	C	lamellipodium
GO:0005942	ISS:BHF-UCL	C	phosphatidylinositol 3-kinase complex
GO:0005943	IDA:UniProtKB	C	phosphatidylinositol 3-kinase complex, class IA
GO:0005886	IBA:RefGenome	C	plasma membrane
GO:0016303	IDA:UniProtKB	F	1-phosphatidylinositol-3-kinase activity
GO:0035005	IBA:RefGenome	F	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0016301	TAS:Reactome	F	kinase activity
GO:0035004	TAS:UniProtKB	F	phosphatidylinositol 3-kinase activity
GO:0046934	TAS:Reactome	F	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0030295	IEA:Ensembl	F	protein kinase activator activity
GO:0004674	IEA:UniProtKB-KW	F	protein serine/threonine kinase activity
GO:0001525	IEA:UniProtKB-KW	P	angiogenesis
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0060048	TAS:UniProtKB	P	cardiac muscle contraction
GO:0043542	TAS:UniProtKB	P	endothelial cell migration
GO:0007173	TAS:Reactome	P	epidermal growth factor receptor signaling pathway
GO:0038095	TAS:Reactome	P	Fc-epsilon receptor signaling pathway
GO:0038096	TAS:Reactome	P	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0006006	IEA:Ensembl	P	glucose metabolic process
GO:0044029	IEA:Ensembl	P	hypomethylation of CpG island
GO:0045087	TAS:Reactome	P	innate immune response
GO:0008286	TAS:Reactome	P	insulin receptor signaling pathway
GO:0038028	TAS:UniProtKB	P	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:2000811	IMP:UniProtKB	P	negative regulation of anoikis
GO:2000270	IEA:Ensembl	P	negative regulation of fibroblast apoptotic process
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0006661	TAS:Reactome	P	phosphatidylinositol biosynthetic process
GO:0048015	TAS:Reactome	P	phosphatidylinositol-mediated signaling
GO:0046854	ISS:BHF-UCL	P	phosphatidylinositol phosphorylation
GO:0006644	TAS:Reactome	P	phospholipid metabolic process
GO:0030168	TAS:UniProtKB	P	platelet activation
GO:0033138	IEA:Ensembl	P	positive regulation of peptidyl-serine phosphorylation
GO:0043491	IEA:Ensembl	P	protein kinase B signaling
GO:2000653	IEA:Ensembl	P	regulation of genetic imprinting
GO:0040014	IEA:Ensembl	P	regulation of multicellular organism growth
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0031295	TAS:Reactome	P	T cell costimulation
GO:0050852	TAS:Reactome	P	T cell receptor signaling pathway
GO:0001944	TAS:UniProtKB	P	vasculature development

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04152	AMPK signaling pathway
hsa04024	cAMP signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04550	Signaling pathways regulating pluripotency of stem cells