LMPD Database

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LMP012474

UniProt Annotations

Entry Information
Gene Namesignal transducer and activator of transcription 5B
Protein EntrySTA5B_RAT
UniProt IDP52632
SpeciesRat
Comments
Comment typeDescription
FunctionCarries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (By similarity)
PtmTyrosine phosphorylated. Tyrosine phosphorylated in response to signaling via activated FLT3 and KIT, resulting in translocation to the nucleus. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphoryation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates prolactin signaling pathway (By similarity)
SimilarityBelongs to the transcription factor STAT family
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular LocationCytoplasm . Nucleus . Note=Translocated into the nucleus in response to phosphorylation
SubunitForms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7 (By similarity). Interacts (via SH2 domain) with INSR