LMPD Database

LMP012474

Gene Information

Entrez Gene ID	25126
Gene Name	signal transducer and activator of transcription 5B
Gene Symbol	Stat5b
Species	Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	ISS:UniProtKB	C	cytoplasm
GO:0005829	IDA:RGD	C	cytosol
GO:0005634	IDA:RGD	C	nucleus
GO:0005509	IEA:InterPro	F	calcium ion binding
GO:0003682	IDA:UniProtKB	F	chromatin binding
GO:0003677	IDA:RGD	F	DNA binding
GO:0003690	IDA:RGD	F	double-stranded DNA binding
GO:0046983	ISS:UniProtKB	F	protein dimerization activity
GO:0000979	IEA:Ensembl	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0043565	IDA:RGD	F	sequence-specific DNA binding
GO:0003700	IDA:RGD	F	sequence-specific DNA binding transcription factor activity
GO:0004871	IEA:Ensembl	F	signal transducer activity
GO:0006103	IEA:Ensembl	P	2-oxoglutarate metabolic process
GO:0006953	IDA:RGD	P	acute-phase response
GO:0000255	IEA:Ensembl	P	allantoin metabolic process
GO:0071364	IDA:UniProtKB	P	cellular response to epidermal growth factor stimulus
GO:0071363	ISS:UniProtKB	P	cellular response to growth factor stimulus
GO:0006101	IEA:Ensembl	P	citrate metabolic process
GO:0006600	IEA:Ensembl	P	creatine metabolic process
GO:0046449	IEA:Ensembl	P	creatinine metabolic process
GO:0046543	IEA:Ensembl	P	development of secondary female sexual characteristics
GO:0046544	IEA:Ensembl	P	development of secondary male sexual characteristics
GO:0006631	IEA:Ensembl	P	fatty acid metabolic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0006549	IEA:Ensembl	P	isoleucine metabolic process
GO:0007259	IDA:RGD	P	JAK-STAT cascade
GO:0060397	IEA:Ensembl	P	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0007595	IEA:Ensembl	P	lactation
GO:0019915	IEA:Ensembl	P	lipid storage
GO:0001889	IDA:RGD	P	liver development
GO:0001553	IDA:RGD	P	luteinization
GO:0001779	IEA:Ensembl	P	natural killer cell differentiation
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0045647	IEA:Ensembl	P	negative regulation of erythrocyte differentiation
GO:0006107	IEA:Ensembl	P	oxaloacetate metabolic process
GO:0048541	IEA:Ensembl	P	Peyer's patch development
GO:0042104	IEA:Ensembl	P	positive regulation of activated T cell proliferation
GO:0045579	IEA:Ensembl	P	positive regulation of B cell differentiation
GO:0051272	IMP:RGD	P	positive regulation of cellular component movement
GO:0045588	IEA:Ensembl	P	positive regulation of gamma-delta T cell differentiation
GO:0050729	IEA:Ensembl	P	positive regulation of inflammatory response
GO:0045086	IEA:Ensembl	P	positive regulation of interleukin-2 biosynthetic process
GO:0045931	IEA:Ensembl	P	positive regulation of mitotic cell cycle
GO:0040018	IEA:Ensembl	P	positive regulation of multicellular organism growth
GO:0032825	IEA:Ensembl	P	positive regulation of natural killer cell differentiation
GO:0045954	IEA:Ensembl	P	positive regulation of natural killer cell mediated cytotoxicity
GO:0032819	IEA:Ensembl	P	positive regulation of natural killer cell proliferation
GO:0048661	IMP:RGD	P	positive regulation of smooth muscle cell proliferation
GO:0045944	ISS:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:0042448	IEA:Ensembl	P	progesterone metabolic process
GO:0038161	ISS:UniProtKB	P	prolactin signaling pathway
GO:0030155	IEA:Ensembl	P	regulation of cell adhesion
GO:0030856	IEA:Ensembl	P	regulation of epithelial cell differentiation
GO:0019218	IEA:Ensembl	P	regulation of steroid metabolic process
GO:0006355	IDA:RGD	P	regulation of transcription, DNA-templated
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0045471	IEP:RGD	P	response to ethanol
GO:0001666	IEP:RGD	P	response to hypoxia
GO:0070672	IEA:Ensembl	P	response to interleukin-15
GO:0070669	IEA:Ensembl	P	response to interleukin-2
GO:0070670	IEA:Ensembl	P	response to interleukin-4
GO:0032496	IDA:RGD	P	response to lipopolysaccharide
GO:0043434	IDA:RGD	P	response to peptide hormone
GO:0006105	IEA:Ensembl	P	succinate metabolic process
GO:0019530	IEA:Ensembl	P	taurine metabolic process
GO:0033077	IEA:Ensembl	P	T cell differentiation in thymus
GO:0043029	IEA:Ensembl	P	T cell homeostasis
GO:0006366	IDA:RGD	P	transcription from RNA polymerase II promoter
GO:0006573	IEA:Ensembl	P	valine metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
ko05221	Acute myeloid leukemia
rno05221	Acute myeloid leukemia
ko04062	Chemokine signaling pathway
rno04062	Chemokine signaling pathway
ko05220	Chronic myeloid leukemia
rno05220	Chronic myeloid leukemia
ko04012	ErbB signaling pathway
rno04012	ErbB signaling pathway
rno05161	Hepatitis B
ko05166	HTLV-I infection
rno05166	HTLV-I infection
ko04630	Jak-STAT signaling pathway
rno04630	Jak-STAT signaling pathway
ko05162	Measles
rno05162	Measles
rno05200	Pathways in cancer
ko04917	Prolactin signaling pathway
rno04917	Prolactin signaling pathway
ko05203	Viral carcinogenesis
rno05203	Viral carcinogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953536	Cytokine Signaling in Immune system
5953253	Disease
5953396	Downstream signal transduction
5954321	Growth hormone receptor signaling
5953410	Immune System
5953534	Interleukin-2 signaling
5954001	Interleukin-3, 5 and GM-CSF signaling
5954308	Interleukin-7 signaling
5954400	Nuclear signaling by ERBB4
5954399	Prolactin receptor signaling
5953540	Signaling by ERBB4
5954510	Signaling by FGFR1 fusion mutants
5954511	Signaling by FGFR1 mutants
5953401	Signaling by FGFR in disease
5954512	Signaling by FGFR mutants
5953535	Signaling by Interleukins
5953543	Signaling by Leptin
5953397	Signaling by PDGF
5953541	Signaling by SCF-KIT
5953381	Signal Transduction