LMPD Database

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LMP006760

UniProt Annotations

Entry Information
Gene Nameprostaglandin reductase 2
Protein EntryPTGR2_HUMAN
UniProt IDQ8N8N7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ZADH1b; IsoId=Q8N8N7-1; Sequence=Displayed; Name=2; IsoId=Q8N8N7-2; Sequence=VSP_013526, VSP_013527; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=11.21 uM for 15-keto-PGE2 ; KM=15.87 uM for NADPH ; Vmax=159 nmol/min/mg enzyme for 15-keto-PGE2 ; Vmax=67 nmol/min/mg enzyme for NADPH ;
Catalytic Activity11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H.
FunctionFunctions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).
SimilarityBelongs to the NADP-dependent oxidoreductase L4BD family.
Subcellular LocationCytoplasm .
SubunitMonomer.
Tissue SpecificityWidely expressed.