LMPD Database

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LMP006669

UniProt Annotations

Entry Information
Gene Namephospholipase D family, member 3
Protein EntryPLD3_HUMAN
UniProt IDQ8IV08
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
DiseaseAlzheimer disease 19 (AD19) [MIM
FunctionProbably involved in APP processing.
InteractionP19838:NFKB1; NbExp=2; IntAct=EBI-2689908, EBI-300010;
PtmGlycosylated. {ECO
Sequence CautionSequence=AAB16799.1; Type=Frameshift; Positions=52; Evidence= ;
SimilarityBelongs to the phospholipase D family.
SimilarityContains 2 PLD phosphodiesterase domains.
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type II membrane protein .
SubunitInteracts with APP.
Tissue SpecificityWidely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum. {ECO