LMPD Database

LMP006669

Record overview

LMPD ID	LMP006669
Gene ID	23646
Species	Homo sapiens (Human)
Gene Name	phospholipase D family, member 3
Gene Symbol	PLD3
Synonyms	AD19; HU-K4; HUK4
Alternate names	phospholipase D3; hindIII K4L homolog; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3
Chromosome	19
Map Location	19q13.2
EC Number	3.1.4.4
Summary	This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Orthologs	View orthologs and multiple alignments for PLD3

Proteins

phospholipase D3

Refseq ID:	NP_036400
Protein GI:	166197683
UniProt ID:	Q8IV08
mRNA ID:	NM_012268
Length:	490
RefSeq Status:	REVIEWED

MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNAST
GNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVL
HTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLC
PSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVV
PADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL

phospholipase D3

Refseq ID:	NP_001278240
Protein GI:	605052028
UniProt ID:	Q8IV08
mRNA ID:	NM_001291311
Length:	490
RefSeq Status:	REVIEWED

phospholipase D3
Protein sequence is identical to GI:166197683 (mRNA isoform)

Refseq ID:	NP_001026866
Protein GI:	72534684
UniProt ID:	Q8IV08
mRNA ID:	NM_001031696
Length:	490
RefSeq Status:	REVIEWED

Protein sequence is identical to GI:166197683 (mRNA isoform)