LMPD Database

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LMP001568

UniProt Annotations

Entry Information
Gene Nameprostaglandin reductase 1
Protein EntryPTGR1_HUMAN
UniProt IDQ14914
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14914-1; Sequence=Displayed; Name=2; IsoId=Q14914-2; Sequence=VSP_044652; Note=No experimental confirmation available.;
Catalytic Activity11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13- dienoate + NAD(P)H.
Catalytic ActivityA n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
FunctionFunctions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
SimilarityBelongs to the NADP-dependent oxidoreductase L4BD family.
Subcellular LocationCytoplasm.
SubunitMonomer or homodimer.
Tissue SpecificityHigh expression in the kidney, liver, and intestine but not in leukocytes.