LMPD Database

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LMP001568

Record overview

LMPD IDLMP001568
Gene ID22949
SpeciesHomo sapiens (Human)
Gene Nameprostaglandin reductase 1
Gene SymbolPTGR1
SynonymsLTB4DH; PGR1; ZADH3
Alternate namesprostaglandin reductase 1; PRG-1; 15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; zinc binding alcohol dehydrogenase domain containing 3
Chromosome9
Map Location9q31.3
EC Number1.3.1.-
SummaryThis gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
OrthologsView orthologs and multiple alignments for PTGR1

Proteins

prostaglandin reductase 1 isoform 1
Refseq ID:NP_036344
Protein GI:226059133
UniProt ID:Q14914
mRNA ID:NM_012212
Length:329
RefSeq Status:REVIEWED
MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEGDTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGK
DLEKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLE
ETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKE
YIIEGFENMPAAFMGMLKGDNLGKTIVKA
 
prostaglandin reductase 1 isoform 1
Refseq ID:NP_001139580
Protein GI:226059159
UniProt ID:Q14914
mRNA ID:NM_001146108
Length:329
RefSeq Status:REVIEWED
Protein sequence is identical to GI:226059133 (mRNA isoform)
 
prostaglandin reductase 1 isoform 2
Refseq ID:NP_001139581
Protein GI:226059159
UniProt ID:Q14914
mRNA ID:NM_001146109
Length:329
RefSeq Status:REVIEWED
Protein sequence is identical to GI:226059133 (mRNA isoform)