LMPD Database

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LMP001394

UniProt Annotations

Entry Information
Gene Nameprostaglandin F receptor (FP)
Protein EntryPF2R_HUMAN
UniProt IDP43088
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1; IsoId=P43088-1; Sequence=Displayed; Name=2; Synonyms=FP(S), VAR-1; IsoId=P43088-2; Sequence=VSP_042025; Name=3; Synonyms=VAR-2; IsoId=P43088-3; Sequence=VSP_053589, VSP_053595; Name=4; Synonyms=VAR-3; IsoId=P43088-4; Sequence=VSP_053588, VSP_053596; Name=5; Synonyms=altFP4, VAR-4; IsoId=P43088-5; Sequence=VSP_053593, VSP_053597; Name=6; Synonyms=VAR-5; IsoId=P43088-6; Sequence=VSP_053591, VSP_053592; Name=7; Synonyms=VAR-6; IsoId=P43088-7; Sequence=VSP_053590, VSP_053594;
FunctionReceptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
SubunitIsoform 1 can form heterodimers with isoform 5 (and probably other isoforms).
Tissue SpecificityEye.