LMPD Database

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LMP001394

Record overview

LMPD IDLMP001394
Gene ID5737
SpeciesHomo sapiens (Human)
Gene Nameprostaglandin F receptor (FP)
Gene SymbolPTGFR
SynonymsFP
Alternate namesprostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)
Chromosome1
Map Location1p31.1
SummaryThe protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PTGFR

Proteins

prostaglandin F2-alpha receptor isoform a precursor
Refseq ID:NP_000950
Protein GI:4506261
UniProt ID:P43088
mRNA ID:NM_000959
Length:359
RefSeq Status:REVIEWED
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIR
FDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRF
YLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD
PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
 
prostaglandin F2-alpha receptor isoform b precursor
Refseq ID:NP_001034674
Protein GI:88758606
UniProt ID:P43088
mRNA ID:NM_001039585
Length:297
RefSeq Status:REVIEWED
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIR
FDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRF
YLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRLQWPTLE
 
sig_peptide: 1..25
calculated_mol_wt: 2640
peptide sequence: 
MSMNNSKQLVSPAAALLSNTTCQTE

mat_peptide: 26..359
product: prostaglandin F2-alpha receptor isoform a
calculated_mol_wt: 37433
peptide sequence: 
NRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLL
GSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGI
TLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGV
HVISLHIWELSSIKNSLKVAAISESPVAEKSAST

sig_peptide: 1..25
calculated_mol_wt: 2640
peptide sequence: 
MSMNNSKQLVSPAAALLSNTTCQTE

mat_peptide: 26..297
product: prostaglandin F2-alpha receptor isoform b
calculated_mol_wt: 31031
peptide sequence: 
NRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLL
GSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGI
TLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRLQWPTLE