LMPD Database

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LMP001324

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IIA (platelets, synovial fluid)
Protein EntryPA2GA_MOUSE
UniProt IDP31482
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
FunctionMay play a role in cell proliferation, by increasing the binding of EGF to the cells and thereby modulating its action. In doing so, this isozyme binds to a membrane-associated receptor distinct from the EGF receptor and which could be a heparan- sulfate proteoglycan located on the cell membrane.
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
PolymorphismIn strains 129/Sv, B10.RIII and C57BL/6, a polymorphism causes a frameshift and premature truncation of the protein, rendering it inactive. Strains BALB/c, C3H/He, DBA/1, DBA/2, MRL and NZB/B1N contain the normal protein while strain CD- 1 is heterozygous for the mutation.
Sequence CautionSequence=AAB06315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationMembrane; Peripheral membrane protein.
Tissue SpecificityMainly in the Paneth cells adjacent to the stem population in the small intestines. Also expressed in regenerating liver and hyperplastic esophageal epithelium.