LMPD Database

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LMP001272

UniProt Annotations

Entry Information
Gene Namehydroxyprostaglandin dehydrogenase 15-(NAD)
Protein EntryPGDH_HUMAN
UniProt IDP15428
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=P15428-1; Sequence=Displayed; Name=2; IsoId=P15428-2; Sequence=VSP_043032; Name=3; IsoId=P15428-3; Sequence=VSP_045106; Name=4; IsoId=P15428-4; Sequence=VSP_045107, VSP_045108; Name=5; IsoId=P15428-5; Sequence=VSP_045579; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3.4 uM for prostaglandin E2 ; KM=38 uM for NAD ;
Catalytic Activity(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost- 5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15- dioxoprost-5,13-dienoate + NADH.
DiseaseCranioosteoarthropathy (COA) [MIM
DiseaseHypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM
DiseaseIsolated congenital nail clubbing (ICNC) [MIM
FunctionProstaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. {ECO
InductionDown-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular LocationCytoplasm.
SubunitHomodimer.
Tissue SpecificityDetected in colon epithelium (at protein level).
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/hpgd/";