LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000453

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily E, polypeptide 1
Protein EntryCP2E1_HUMAN
UniProt IDP05181
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI
FunctionMetabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
InductionBy ethanol and isoniazid.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2E1 alleles; URL="http://www.cypalleles.ki.se/cyp2e1.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2e1/";
Web ResourceName=Wikipedia; Note=CYP2E1 entry; URL="http://en.wikipedia.org/wiki/CYP2E1";