MS-DIAL

A program to facilitate metabolomics and lipidomics oriented life science

Description

MS-DIAL is an open-source, vendor-neutral software platform for untargeted metabolomics and lipidomics data analysis. It supports a wide range of mass spectrometry modalities—including DDA, DIA, GC–MS, LC–MS, ion mobility MS, and MSI—enabling researchers to process complex datasets from raw spectral deconvolution to metabolite/lipid annotation. MS-DIAL provides automated peak detection, alignment, and annotation using both public spectral libraries and decision-tree based algorithms, while advanced algorithms such as retention-time prediction, ion mobility filtering, and fragment-ion networking improve annotation accuracy. The newest generation (MS-DIAL 5) introduces data mining for different modality of mass fragmentations such as OAD and EAD, and dual-dimensional deconvolution in ZT Scan DIA. Designed to maximize accessibility and reproducibility, MS-DIAL integrates seamlessly with community repositories (e.g., MassBank, GNPS). Its intuitive interface and robust algorithms make MS-DIAL a widely adopted tool for life sciences using mass spectrometry.