LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012782

UniProt Annotations

Entry Information
Gene Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Protein EntryPRGC1_RAT
UniProt IDQ9QYK2
SpeciesRat
Comments
Comment typeDescription
FunctionTranscriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)
InductionUp-regulated in brown adipose tissue of diabetic fatty (fa/fa) rats. Exposure of fa/fa rats to cold resulted in a much smaller increase as compared to lean rats in which a 2.6 fold increase was seen. Leptin is required for normal basal and cold- stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. It is induced not only by cold exposure but also by prolonged low-intensity physical exercise in epitrochlearis muscle. {ECO:0000269|PubMed:10913342, ECO:0000269|PubMed:11108270}.
PtmHeavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions (By similarity)
PtmPhosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2
PtmUbiquitinated. Ubiquitination by RNF34 induces proteasomal degradation
SimilarityContains 1 RRM (RNA recognition motif) domain
Subcellular LocationNucleus . Nucleus, PML body .
SubunitHomooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger)