LIPID MAPS® Gene/Proteome Database (LMPD)

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LMPD Record

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LMP012782

Gene Information

Entrez Gene ID83516
Gene Nameperoxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene SymbolPpargc1a
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:RGDCcytosol
GO:0005634 IDA:RGDCnucleus
GO:0003682 IDA:RGDFchromatin binding
GO:0031490 ISS:UniProtKBFchromatin DNA binding
GO:0003677 ISS:UniProtKBFDNA binding
GO:0030374 IEA:EnsemblFligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterProFnucleotide binding
GO:0003723 IEA:UniProtKB-KWFRNA binding
GO:0043565 ISS:UniProtKBFsequence-specific DNA binding
GO:0003713 IDA:RGDFtranscription coactivator activity
GO:0008209 IEP:RGDPandrogen metabolic process
GO:0071398 IEP:RGDPcellular response to fatty acid
GO:0071456 IEP:RGDPcellular response to hypoxia
GO:0071250 IEP:RGDPcellular response to nitrite
GO:0034599 ISS:UniProtKBPcellular response to oxidative stress
GO:0097067 IEP:RGDPcellular response to thyroid hormone stimulus
GO:0071356 IEP:RGDPcellular response to tumor necrosis factor
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0051552 IEP:RGDPflavone metabolic process
GO:0006012 IEP:RGDPgalactose metabolic process
GO:0007005 IMP:RGDPmitochondrion organization
GO:0045820 IMP:RGDPnegative regulation of glycolytic process
GO:0043524 ISS:UniProtKBPnegative regulation of neuron apoptotic process
GO:1901215 ISS:UniProtKBPnegative regulation of neuron death
GO:2000272 IMP:RGDPnegative regulation of receptor activity
GO:0014912 IMP:RGDPnegative regulation of smooth muscle cell migration
GO:0070997 IEA:EnsemblPneuron death
GO:2001171 ISS:UniProtKBPpositive regulation of ATP biosynthetic process
GO:0031325 IMP:RGDPpositive regulation of cellular metabolic process
GO:1901857 IEA:EnsemblPpositive regulation of cellular respiration
GO:2000507 ISS:UniProtKBPpositive regulation of energy homeostasis
GO:0046321 IMP:RGDPpositive regulation of fatty acid oxidation
GO:1901860 IEA:EnsemblPpositive regulation of mitochondrial DNA metabolic process
GO:0010822 ISS:UniProtKBPpositive regulation of mitochondrion organization
GO:1901863 IEA:EnsemblPpositive regulation of muscle tissue development
GO:0051091 ISS:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IMP:RGDPpositive regulation of smooth muscle cell proliferation
GO:0045893 IMP:RGDPpositive regulation of transcription, DNA-templated
GO:0045944 ISS:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0042752 ISS:UniProtKBPregulation of circadian rhythm
GO:2000310 IMP:RGDPregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0006355 ISS:UniProtKBPregulation of transcription, DNA-templated
GO:0022904 ISS:UniProtKBPrespiratory electron transport chain
GO:0014823 IEP:RGDPresponse to activity
GO:0009409 IEP:RGDPresponse to cold
GO:0042493 IEP:RGDPresponse to drug
GO:0071871 IEP:RGDPresponse to epinephrine
GO:0001666 IEP:RGDPresponse to hypoxia
GO:0043201 IEP:RGDPresponse to leucine
GO:0014850 ISS:UniProtKBPresponse to muscle activity
GO:0071873 IEP:RGDPresponse to norepinephrine
GO:0031667 IEP:RGDPresponse to nutrient levels
GO:0014070 IEP:RGDPresponse to organic cyclic compound
GO:0042594 IEP:RGDPresponse to starvation
GO:0036273 IEP:RGDPresponse to statin
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
KEGG Pathway Links
KEGG Pathway IDDescription
ko04920Adipocytokine signaling pathway
rno04920Adipocytokine signaling pathway
ko04152AMPK signaling pathway
rno04152AMPK signaling pathway
ko05016Huntington's disease
rno05016Huntington's disease
ko04910Insulin signaling pathway
rno04910Insulin signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
5954481Activation of PPARGC1A (PGC-1alpha) by phosphorylation
5954332BMAL1:CLOCK,NPAS2 activates circadian gene expression
5954223Circadian Clock
5953533Developmental Biology
5953288Fatty acid, triacylglycerol, and ketone body metabolism
5953250Metabolism
5953289Metabolism of lipids and lipoproteins
5953600Mitochondrial biogenesis
5953601Organelle biogenesis and maintenance
5954333PPARA activates gene expression
5954222Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954224REV-ERBA represses gene expression
5954225RORA activates circadian gene expression
5953599Transcriptional activation of mitochondrial biogenesis
5954166Transcriptional regulation of white adipocyte differentiation