LIPID MAPS

Isodeoxycholic acid is a bile acid and an agonist of the farnesoid X receptor (FXR).¹ It induces FXR-mediated gene expression in a reporter assay using COS-7 cells when used at a concentration of 30 µM. Isodeoxycholic acid also activates large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rabbit superior mesenteric arteries.²

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References

1. T., S., Tamehiro, N., Sato, Y., et al. The novel compounds that activate farnesoid X receptor: The diversity of their effects on gene expression. J. Pharmacol. Sci. 107(3), 285-294 (2008).

2. Dopico, A.M., Walsh, J.V., and Singer, J.J. Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells. J. Gen. Physiol. 119(3), 251-273 (2002).

References

Taxonomy Information

Curated from

NCBI taxonomy class

Reference

synthetic construct (#32630)

Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells.,
J Gen Physiol, 2002

Pubmed ID: 11865021

String Representations

InChiKey (Click to copy)

ZHCAAZIHTDCFJX-QLEQUTGBSA-N

InChi (Click to copy)

InChI=1S/C24H40O4/c1-14(7-10-21(27)28)16-8-9-17-22-18(13-20(26)24(16,17)3)23(2)11-5-4-6-15(23)12-19(22)25/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

SMILES (Click to copy)

C1[C@]2(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@@]([H])([C@]([H])(C)CCC(O)=O)CC[C@@]4([H])[C@]3([H])[C@H](O)C[C@]2([H])CCC1