Rhodojaponin III is a diterpenoid that has been found in R. molle and has insecticidal and antinociceptive activities.^1,2 It reduces pupation and the number of Colorado potato beetle (L. decemlineata) larvae on, and damage to, potato plants when applied at concentrations of 75 and 150 ppm.¹ It also induces mortality in adult confused flour beetles (T. confusum). Rhodojaponin III has antinociceptive effects in mouse models of chemical, inflammatory, and neuropathic pain.² It reduces acetic acid-induced writhing in mice (ID50 = 0.0469 mg/kg) and increases the paw withdrawal threshold for mechanical stimuli in a mouse model of diabetic peripheral neuropathic pain when administered at doses of 0.04 and 0.08 mg/kg. Rhodojaponin III is toxic to mice with an LD50 value of 0.271 mg/kg.