Structure Database (LMSD)
Common Name
1,8-Cineol
Systematic Name
1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane
Synonyms
- Eucalyptol
- 1,8-Epoxy-p-menthane
- cajeputol
3D model of 1,8-Cineol
Please note: Where there are chiral atoms but the stereochemistry is undefined, the 3D model takes an arbitrary conformation
Classification
Category
Main Class
Sub Class
Level 4 Class
Biological Context
Eucalyptol is a bicyclic monoterpene that has been found in Eucalyptus and other plants, including C. sativa and has diverse biological activities, including anti-inflammatory, decongestant, antinociceptive, and insect repellent properties.1,2,3,4,5 Eucalyptol (10 μM) inhibits TNF-α, IL-1β, IL-4, and IL-5 production by primary human lymphocytes stimulated by ionomycin and phorbol 12-myristate 13-acetate (PMA).2 It also decreases LPS-induced mucus production by primary human nasal turbinate slices when used at a concentration of 10 μM.3 Eucalyptol (400 mg/kg) decreases carrageenan-induced hind paw edema in rats and reduces the time spent licking the hind paw in a formalin-induced nociception test in mice.4 It inhibits A. aegypti mosquitoes from feeding on anesthetized gerbils when applied topically at a concentration of 10% and from laying eggs in an ovipositional bioassay when used at a concentration of 1% in standing water.5 Formulations containing eucalyptol have been used in mouthwash and cough suppressants.
This information has been provided by Cayman Chemical
References
References
String Representations
InChiKey (Click to copy)
WEEGYLXZBRQIMU-UHFFFAOYSA-N
InChi (Click to copy)
InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3
SMILES (Click to copy)
C12(C)CCC(CC1)C(C)(C)O2
Other Databases
Wikipedia
KEGG ID
HMDB ID
PubChem CID
Cayman ID
GuidePharm ID
Calculated Physicochemical Properties
Heavy Atoms
11
Rings
3
Aromatic Rings
0
Rotatable Bonds
0
Van der Waals Molecular Volume
161.83
Topological Polar Surface Area
11.30
Hydrogen Bond Donors
0
Hydrogen Bond Acceptors
1
logP
3.32
Molar Refractivity
46.55
Admin
Created at
-
Updated at
20th Feb 2025