Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities.^1,2,3 It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2) production in RAW 264.7 cells when used at a concentration of 1.6 µM.¹ Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells.² In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.³