Gene/Proteome Database (LMPD)

LMPD ID
LMP014734
Gene ID
703407
Species
Macaca mulatta (Rhesus monkey)
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
PTGIS
Alternate Names
prostaglandin I2 (prostacyclin) synthase;
Chromosome
10
Map Location
chromosome:10
EC Number
5.3.99.4

Proteins

Refseq ID XP_001098575
Protein GI 109091639
UniProt ID F7F0C0
mRNA ID XM_001098575
Length 500
MTWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWESRTRLDFHAYAVFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYTNLHTVLLGDATEAGSGWHEMGLLDFSYSSLLRAGYLTLYGIEALPRTHQSQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWEAEQPVSQMTTLPQKVLDGTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGKSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPIRYRIRP

Gene Information

Entrez Gene ID
703407
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
PTGIS
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005901 ISS:UniProtKB C caveola
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0005615 ISS:UniProtKB C extracellular space
GO:0005634 ISS:UniProtKB C nucleus
GO:0020037 IBA:RefGenome F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116 ISS:UniProtKB F prostaglandin-I synthase activity
GO:0097190 IEA:Ensembl P apoptotic signaling pathway
GO:0071456 ISS:UniProtKB P cellular response to hypoxia
GO:0071347 ISS:UniProtKB P cellular response to interleukin-1
GO:0071354 ISS:UniProtKB P cellular response to interleukin-6
GO:0032088 ISS:UniProtKB P negative regulation of NF-kappaB transcription factor activity
GO:0050728 ISS:UniProtKB P negative regulation of inflammatory response
GO:0045019 ISS:UniProtKB P negative regulation of nitric oxide biosynthetic process
GO:0045766 ISS:UniProtKB P positive regulation of angiogenesis
GO:1900119 ISS:UniProtKB P positive regulation of execution phase of apoptosis
GO:0035360 ISS:UniProtKB P positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0001516 ISS:UniProtKB P prostaglandin biosynthetic process
GO:0042981 IBA:RefGenome P regulation of apoptotic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
mcc00590 Arachidonic acid metabolism
mcc01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
IPR027286 Prostacyclin synthase

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) synthase
Protein Entry
F7F0C0_MACMU
UniProt ID
F7F0C0
Species
Rhesus monkey

Comments

Comment Type Description
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11- alpha,15-dihydroxyprosta-5,13-dienoate.
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Cofactor Note=Heme group. ;
Function Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane

Identical and Related Proteins

Unique RefSeq proteins for LMP014734 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
109091639 RefSeq XP_001098575 500 prostaglandin I2 (prostacyclin) synthase

Identical Sequences to LMP014734 proteins

Reference Database Accession Length Protein Name
GI:109091639 RefSeq XP_005569380.1 500 PREDICTED: prostacyclin synthase [Macaca fascicularis]

Related Sequences to LMP014734 proteins

Reference Database Accession Length Protein Name
GI:109091639 RefSeq XP_003252967.1 500 PREDICTED: prostacyclin synthase [Nomascus leucogenys]
GI:109091639 RefSeq XP_008012673.1 500 PREDICTED: prostacyclin synthase [Chlorocebus sabaeus]
GI:109091639 RefSeq XP_010382153.1 500 PREDICTED: prostacyclin synthase [Rhinopithecus roxellana]