Gene/Proteome Database (LMPD)
Proteins
| Refseq ID | XP_001098061 |
| Protein GI | 297292025 |
| mRNA ID | XM_001098061 |
| Length | 1503 |
| MRTALPVGKLEGGYGWQHLAEGLVMEVNNILGWGHTFWALLASPIMEHKEVVLLLLLFLKSALPEQSHVVQDCYHGDGQSYQGTSSTTVTGRTCQAWSSMEPHQHNRTTENYPNAGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGTAVAPPNVTLVPSLEAPSEQSPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPNVRWEYCNLTQCSDAEGIAVTPLTVTPVPSLEAPSKQAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGSPTSSDLLVYPAVFLDAMGPTVLSTHPLSLSPGVAATSRGYIESKREAPTEQRPGVQECYHGNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNGGLIRNYCRNPDPVAAPYCYTMDPSVRWEYCNLTQCSDAEGTAVAPPNVTPVPSLEAPSEQAPTEQRLGVQECYHSNGQSYRGTYFTTVTGRTCQAWSSMTPHSHSRTPENYPNAGLVKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEGTAVVPPNIIPVPSLEAFLEQEPTEETPGVQECYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPKNYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLETLTVVPDPSTQASSEEAPTEQSPEVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPDGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLATSMAVSEQAPMEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTIEYYPNGGLTKNYCRNPDAEIRPWCYTMDPRVRWEYCNLTQCVVMESSVLATPMVVPVPSREVPSEEAPTENSPGVQDCYQGDGQSYRGTFSTTITGRTCQSWLSMTPHRHRRIPLRYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVTESSVLTTPTVVPVPSTEAPSEQAPPEKSPVVQDCYHGDGQSYRGTSSTTVTGRNCQSWSSMIPHWHQRTPENYPNAGLTRNYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVQQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHQHKRTPENHPNDGLTMNYCRNPDADTGPWCFTMDPSVRREYCNLTRCSDTEGTVVTPPTVIPVPSLEAPSEQASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAACCLETFSRPSFYKVILGAHQEVNLESHVQEIEVSRLFLEPIGADIALLKLSRPAIITDKVIPACLPSPNYVITAWTECYITGWGETQGEIKSIAHGDNGGPVVCFDKDKYILRGITSWGPGCACPNKPGVYVRVSSFVTWIEGVMRNN | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0004252 | IEA:InterPro | F | serine-type endopeptidase activity |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lipoprotein, Lp(a)
Species
Rhesus monkey
Comments
| Comment Type | Description |
|---|---|
| Disease | Note=Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding. |
| Function | Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. |
| Miscellaneous | Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation (By similarity). {ECO:0000250}. |
| Ptm | N- and O-glycosylated. {ECO:0000250}. |
| Similarity | Belongs to the peptidase S1 family. Plasminogen subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}. |
| Similarity | Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE- ProRule:PRU00274}. |
| Similarity | Contains at least 10 kringle domains. {ECO:0000305}. |
| Subunit | Disulfide-linked to apo-B100. Binds to fibronectin and decorin (By similarity). {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP014311 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 297292025 | RefSeq | XP_001098061 | 1503 |
Identical Sequences to LMP014311 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|
Related Sequences to LMP014311 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:297292025 | GenBank | AAA36833.1 | 1420 | apolipoprotein(a), partial [Macaca mulatta] |
| GI:297292025 | RefSeq | XP_005551556.1 | 1543 | PREDICTED: apolipoprotein(a) [Macaca fascicularis] |
| GI:297292025 | RefSeq | XP_008006112.1 | 2116 | PREDICTED: apolipoprotein(a) [Chlorocebus sabaeus] |
| GI:297292025 | SwissProt | P14417.1 | 1420 | RecName: Full=Apolipoprotein(a); Short=Apo(a); Short=Lp(a), partial [Macaca mulatta] |