LIPID MAPS

LMPD ID

LMP014299

Gene ID

699244

Species

Macaca mulatta (Rhesus monkey)

Gene Name

lipoic acid synthetase

Gene Symbol

LIAS

Alternate Names

lipoyl synthase, mitochondrial;

Chromosome

5

Map Location

chromosome:5

EC Number

2.8.1.8

lipoyl synthase, mitochondrial
Refseq ID	NP_001248031
Protein GI	386780746
UniProt ID	F6RMC6
mRNA ID	NM_001261102
Length	372
Protein sequence is identical to GI:109074017 (mRNA isoform)


Refseq ID	XP_001091994
Protein GI	109074017
UniProt ID	F6RMC6
mRNA ID	XM_001091994
Length	372
MSLRCGDAARTLGPRVFGRYLCSPVRPLSSLPDEKKELLQNGPDLQDFVSGDLADRSTWVEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKAL


Refseq ID	XP_001091641
Protein GI	109074019
UniProt ID	F6RMC6
mRNA ID	XM_001091994
Length	322
MSLRCGDAARTLGPRVFGRYLCSPVRPLSSLPDEKKELLQNGPDLQDFVSGDLADRSTWVEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVNFS

Entrez Gene ID

699244

Gene Name

lipoic acid synthetase

Gene Symbol

LIAS

Species

Macaca mulatta

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005739	IEA:UniProtKB-SubCell	C	mitochondrion
GO:0051539	IEA:UniProtKB-HAMAP	F	4 iron, 4 sulfur cluster binding
GO:0016992	IEA:UniProtKB-HAMAP	F	lipoate synthase activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0001843	IEA:Ensembl	P	neural tube closure
GO:0009249	IEA:UniProtKB-HAMAP	P	protein lipoylation
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0006979	IEA:Ensembl	P	response to oxidative stress

KEGG Pathway Links

KEGG Pathway ID	Description
ko00785	Lipoic acid metabolism
mcc00785	Lipoic acid metabolism
mcc01100	Metabolic pathways

InterPro Annotations

Accession	Description
IPR013785	Aldolase-type TIM barrel
IPR006638	Elongator protein 3/MiaB/NifB
IPR003698	Lipoyl synthase
IPR007197	Radical SAM

Entry Information

Gene Name

lipoic acid synthetase

Protein Entry

F6RMC6_MACMU

UniProt ID

F6RMC6

Species

Rhesus monkey

Comments

Comment Type	Description
Catalytic Activity	Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L- methionine + 2 5'-deoxyadenosine. {ECO:0000256\|HAMAP- Rule:MF_03123}.
Cofactor	Note=Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. ;
Function	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Pathway	Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 2/2.
Similarity	Belongs to the radical SAM superfamily. Lipoyl synthase family.
Subcellular Location	Mitochondrion {ECO:0000256\|HAMAP- Rule:MF_03123}.

Unique RefSeq proteins for LMP014299 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
109074017	RefSeq	XP_001091994	372	lipoic acid synthetase
109074019	RefSeq	XP_001091641	322	lipoic acid synthetase

Identical Sequences to LMP014299 proteins

Reference	Database	Accession	Length	Protein Name
GI:386780746	GenBank	EHH25816.1	372	Lipoyl synthase, mitochondrial [Macaca mulatta]
GI:386780746	GenBank	AFE65269.1	372	lipoyl synthase, mitochondrial isoform 1 precursor [Macaca mulatta]
GI:386780746	GenBank	AFE65270.1	372	lipoyl synthase, mitochondrial isoform 1 precursor [Macaca mulatta]