Gene/Proteome Database (LMPD)

LMPD ID
LMP014297
Gene ID
698728
Species
Macaca mulatta (Rhesus monkey)
Gene Name
leptin
Gene Symbol
LEP
Synonyms
OB;
Alternate Names
leptin; obesity factor;
Chromosome
3
Map Location
chromosome:3

Proteins

leptin precursor
Refseq ID NP_001036220
Protein GI 112363109
UniProt ID Q28504
mRNA ID NM_001042755
Length 167
MYWRTLWGFLWLWPYLFYIQAVPIQKVQSDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIPGLHPVLTLSQMDQTLAIYQQILINLPSRNVIQISNDLENLRDLLHLLAFSKSCHLPLASGLETLESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2854 peptide sequence: MYWRTLWGFLWLWPYLFYIQA mat_peptide: 22..167 product: Leptin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q28504.1) calculated_mol_wt: 16117 peptide sequence: VPIQKVQSDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIPGLHPVLTLSQMDQTLAIYQQILINLPSRNVIQISNDLENLRDLLHLLAFSKSCHLPLASGLETLESLGDVLEASLYSTEVVALSRLQGSLQDMLWQLDLSPGC

Gene Information

Entrez Gene ID
698728
Gene Name
leptin
Gene Symbol
LEP
Species
Macaca mulatta

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 ISS:HGNC C extracellular space
GO:0008343 ISS:HGNC P adult feeding behavior
GO:0032099 ISS:HGNC P negative regulation of appetite
GO:0007165 IEA:InterPro P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
mcc04152 AMPK signaling pathway
ko04920 Adipocytokine signaling pathway
mcc04920 Adipocytokine signaling pathway
ko04060 Cytokine-cytokine receptor interaction
mcc04060 Cytokine-cytokine receptor interaction
ko04630 Jak-STAT signaling pathway
mcc04630 Jak-STAT signaling pathway
ko04080 Neuroactive ligand-receptor interaction
mcc04080 Neuroactive ligand-receptor interaction
ko04932 Non-alcoholic fatty liver disease (NAFLD)
mcc04932 Non-alcoholic fatty liver disease (NAFLD)

Domain Information

InterPro Annotations

Accession Description
IPR012351 Four-helical cytokine, core
IPR009079 Four-helical cytokine-like, core
IPR000065 Leptin

UniProt Annotations

Entry Information

Gene Name
leptin
Protein Entry
LEP_MACMU
UniProt ID
Q28504
Species
Rhesus monkey

Comments

Comment Type Description
Function May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Similarity Belongs to the leptin family.
Subcellular Location Secreted

Identical and Related Proteins

Unique RefSeq proteins for LMP014297 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
112363109 RefSeq NP_001036220 167 leptin precursor

Identical Sequences to LMP014297 proteins

Reference Database Accession Length Protein Name
GI:112363109 GenBank AAC50730.1 167 leptin [Macaca mulatta]
GI:112363109 GenBank ACM96533.1 167 Sequence 33 from patent US 7470669
GI:112363109 GenBank EHH52483.1 167 hypothetical protein EGM_12933 [Macaca fascicularis]
GI:112363109 SwissProt Q28504.1 167 RecName: Full=Leptin; AltName: Full=Obesity factor; Flags: Precursor [Macaca mulatta]

Related Sequences to LMP014297 proteins

Reference Database Accession Length Protein Name