Gene/Proteome Database (LMPD)

LMPD ID
LMP013651
Gene ID
100361138
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, theta
Gene Symbol
Dgkq
Alternate Names
diacylglycerol kinase theta;
Chromosome
14
Map Location
14p22
EC Number
2.7.1.107

Proteins

diacylglycerol kinase theta
Refseq ID NP_001185733
Protein GI 311771720
UniProt ID D3ZEY4
mRNA ID NM_001198804
Length 937
MATAAESGARTWPGSGSPRLGSPAGSPVLGISGRARPGSGPERTGRAIGSVAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKQVKTPCTSIAPSLVRVPVAHCFGSLGLYKRKFCVVCRKSLEVPAFRCEVCELHVHPDCVPFACSDCRQCHQDGQHDYDTYHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSVCSTALTPECTFGRLRSMVLPPSCVRLLSRNFSKMHCFRIPETMVLELGDGDDGLDGSAAVGTGREVSAATESTKQTLKIFDGNDSMRKNQFRLVTVSRLARNEEVMEAALRAYYINEDPKDFQLQALPLTLLSGNAQALGKAGTTEEETSKDSGPGDSVPEAWVIRSLPRTQEILKIYPDWLKVGVAYVSIRVNSQSTARSVVQEVLPLFGRQVEDQERFQLIEVLMSSRQVQRTVLVDEEPLLDRLRDIRQTSVRQASQTRFYVAEARAVTPHVSLFVGGLPPGLSPQDYSNLLHEAMATKAAVVSVSHVYSLQGAVVLDVTCFAEAERLYMLARDTAVHGRPLTALVLPDVLHTKLPPDCCPLLVFVNPKSGGLKGRELLCSFRKLLNPHQVFELTNGGPLPGFHLFSQVPCFRVLVCGGDGTVGWVLAALEETRRHLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLVSVDEADAVLMDRWTILLDAHEIDSTENNVVETEPPKIVQMNNYCGIGIDAELSLDFHQAREEEPGKFTSRFHNKGVYVRVGLQKISHSRSLHKEIRLQVEQQEVELPSIEGLIFINIPSWGSGADLWGSDSDSRFEKPRIDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWIQAPGHMIISATAPKVHMLRKAKQKPRKAGAIRDTRVDTLPAPEGNPL

Gene Information

Entrez Gene ID
100361138
Gene Name
diacylglycerol kinase, theta
Gene Symbol
Dgkq
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005856 IEA:Ensembl C cytoskeleton
GO:0005829 IEA:Ensembl C cytosol
GO:0016607 IEA:Ensembl C nuclear speck
GO:0005886 IEA:Ensembl C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:UniProtKB-EC F diacylglycerol kinase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0019933 IEA:Ensembl P cAMP-mediated signaling
GO:0070528 IEA:Ensembl P protein kinase C signaling
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0006357 IEA:Ensembl P regulation of transcription from RNA polymerase II promoter
GO:0033198 IEA:Ensembl P response to ATP
GO:0070493 IEA:Ensembl P thrombin receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953655 Effects of PIP2 hydrolysis
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR000159 Ras-association
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, theta
Protein Entry
D3ZEY4_RAT
UniProt ID
D3ZEY4
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain
Similarity Contains 2 Ras-associating domains
Similarity Contains 3 phorbol-ester/DAG-type zinc fingers

Identical and Related Proteins

Unique RefSeq proteins for LMP013651 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
311771720 RefSeq NP_001185733 937 diacylglycerol kinase theta

Identical Sequences to LMP013651 proteins

Reference Database Accession Length Protein Name
GI:311771720 GenBank EDL84024.1 937 rCG57232, isoform CRA_b [Rattus norvegicus]

Related Sequences to LMP013651 proteins

Reference Database Accession Length Protein Name
GI:311771720 GenBank EDL20093.1 934 diacylglycerol kinase, theta, isoform CRA_a [Mus musculus]
GI:311771720 GenBank EDL84024.1 937 rCG57232, isoform CRA_b [Rattus norvegicus]
GI:311771720 RefSeq NP_950176.1 934 diacylglycerol kinase theta [Mus musculus]
GI:311771720 SwissProt Q6P5E8.1 934 RecName: Full=Diacylglycerol kinase theta; Short=DAG kinase theta; AltName: Full=Diglyceride kinase theta; Short=DGK-theta [Mus musculus]