Gene/Proteome Database (LMPD)

LMPD ID
LMP013558
Gene ID
494342
Species
Rattus norvegicus (Rat)
Gene Name
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Gene Symbol
B4galt3
Alternate Names
beta-1,4-galactosyltransferase 3; b4Gal-T3; beta4Gal-T3; beta-1,4-GalTase 3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3;
Chromosome
13
Map Location
13q24
EC Number
2.4.1.-

Proteins

beta-1,4-galactosyltransferase 3
Refseq ID NP_001009539
Protein GI 57164019
UniProt ID Q6P768
mRNA ID NM_001009539
Length 395
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPGAPGAAGAPLAQVLPDCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPHGSH

Gene Information

Entrez Gene ID
494342
Gene Name
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Gene Symbol
B4galt3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003945 IEA:UniProtKB-EC F N-acetyllactosamine synthase activity
GO:0003831 IEA:UniProtKB-EC F beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00533 Glycosaminoglycan biosynthesis - keratan sulfate
rno00533 Glycosaminoglycan biosynthesis - keratan sulfate
ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series
rno00601 Glycosphingolipid biosynthesis - lacto and neolacto series
M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
rno01100 Metabolic pathways
ko00510 N-Glycan biosynthesis
rno00510 N-Glycan biosynthesis
M00075 N-glycan biosynthesis, complex type
ko00514 Other types of O-glycan biosynthesis
rno00514 Other types of O-glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953253 Disease
5953252 Glycogen storage diseases
5953861 Glycosaminoglycan metabolism
5954344 Keratan sulfate biosynthesis
5954345 Keratan sulfate/keratin metabolism
5953870 MPS I - Hurler syndrome
5953869 MPS II - Hunter syndrome
5953872 MPS IIIA - Sanfilippo syndrome A
5953864 MPS IIIB - Sanfilippo syndrome B
5953867 MPS IIIC - Sanfilippo syndrome C
5953871 MPS IIID - Sanfilippo syndrome D
5953866 MPS IV - Morquio syndrome A
5953873 MPS IV - Morquio syndrome B
5953862 MPS IX - Natowicz syndrome
5953865 MPS VI - Maroteaux-Lamy syndrome
5953868 MPS VII - Sly syndrome
5953250 Metabolism
5953249 Metabolism of carbohydrates
5953345 Metabolism of proteins
5953863 Mucopolysaccharidoses
5953251 Myoclonic epilepsy of Lafora
5954395 N-Glycan antennae elongation
5954394 N-glycan antennae elongation in the medial/trans-Golgi
5953728 Post-translational protein modification
5954050 Transport to the Golgi and subsequent modification

Domain Information

InterPro Annotations

Accession Description
IPR003859 Beta-1,4-galactosyltransferase
IPR027791 Galactosyltransferase, C-terminal
IPR027995 Galactosyltransferase, N-terminal
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Protein Entry
B4GT3_RAT
UniProt ID
Q6P768
Species
Rat

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.
Catalytic Activity UDP-alpha-D-galactose + N-acetyl-beta-D- glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N- acetyl-beta-D-glucosaminylglycopeptide.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 7 family
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein . Note=Trans cisternae of Golgi stack

Identical and Related Proteins

Unique RefSeq proteins for LMP013558 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57164019 RefSeq NP_001009539 395 beta-1,4-galactosyltransferase 3

Identical Sequences to LMP013558 proteins

Reference Database Accession Length Protein Name
GI:57164019 GenBank EDL94620.1 395 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [Rattus norvegicus]
GI:57164019 RefSeq XP_006250315.1 395 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X1 [Rattus norvegicus]
GI:57164019 RefSeq XP_006250316.1 395 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X1 [Rattus norvegicus]
GI:57164019 SwissProt Q6P768.1 395 RecName: Full=Beta-1,4-galactosyltransferase 3; Short=Beta-1,4-GalTase 3; Short=Beta4Gal-T3; Short=b4Gal-T3; AltName: Full=UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; AltName: Full=UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; Includes: RecName: Full=N-acetyllactosamine synthase; AltName: Full=Nal synthase; Includes: RecName: Full=Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Includes: RecName: Full=Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase [Rattus norvegicus]

Related Sequences to LMP013558 proteins

Reference Database Accession Length Protein Name
GI:57164019 GenBank AAH61812.1 395 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [Rattus norvegicus]
GI:57164019 GenBank EDL94620.1 395 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 [Rattus norvegicus]
GI:57164019 RefSeq XP_006250315.1 395 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X1 [Rattus norvegicus]
GI:57164019 RefSeq XP_006250316.1 395 PREDICTED: beta-1,4-galactosyltransferase 3 isoform X1 [Rattus norvegicus]